Typifications and new combinations are provided for Boraginaceae from the Mesoamerica region in advance of the treatment for Flora Mesoamericana. In addition, the recognition of the genus Varronia P. Browne as separate from Cordia L. requires new names for various species to be treated in several floristic projects. Cordia skutchii I. M. Johnston is lectotypified, V. tarodaea J. S. Miller is a new name presented for C. longifolia A. DC., and the following new combinations are made: V. andreana (J. Estrada) J. S. Miller, V. buddleoides (Rusby) J. S. Miller, V. bullulata (Killip ex J. Estrada & García-Barriga) J. S. Miller, V. dardani (Taroda) J. S. Miller, V. eggersii (K. Krause) J. S. Miller, V. guanacastensis (Standley) J. S. Miller, V. guaranitica (Chodat & Hassler) J. S. Miller, V. harleyi (Taroda) J. S. Miller, V. intonsa (I. M. Johnston) J. S. Miller, V. lauta (I. M. Johnston) J. S. Miller, V. leucocephala (Moricand) J. S. Miller, V. leucomalloides (Taroda) J. S. Miller, V. linnaei (Stearn) J. S. Miller, V. macrodonta (Killip) J. S. Miller, V. roraimae (I. M. Johnston) J. S. Miller, V. sangrinaria (Gaviria) J. S. Miller, V. setigera (I. M. Johnston) J. S. Miller, V. stenostachya (Killip ex Gaviria) J. S. Miller, V. steyermarkii (Gaviria) J. S. Miller, and V. urticifolia (Chamisso) J. S. Miller.